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Cancer Center

Liver Cancer Risk Factors

Risk factors for liver cancer:

Gender

  •  Men are more likely to get liver cancer than women. This could be because of some of the behaviors listed below.

Race/ethnicity

  • In the United States, Asian Americans and Pacific Islanders have the highest rates of liver cancer, followed by American Indians/Alaska Natives and Hispanics/Latinos, African Americans, and whites.

Chronic viral hepatitis

  • Worldwide, the most common risk factor for liver cancer is long-term (chronic) infection with hepatitis B virus (HBV) or hepatitis C virus (HCV). These infections lead to cirrhosis and are common in many parts of the world. In the United States, hepatitis C is the more common cause of liver cancer, while in other countries, hepatitis B is more common. These viruses can spread from person to person through sharing dirty needles (such as in drug use), unprotected sex, or childbirth. They can also be passed on through blood transfusions but this is rare in the United States since the start of blood product testing for these viruses. People with hepatitis A or hepatitis E infection do not have an increased risk of liver cancer.

Heavy alcohol use

  • Alcohol abuse is a leading cause of cirrhosis in the United States, which in turn is linked with an increased risk of liver cancer.

Cirrhosis

  • Cirrhosis is a disease in which liver cells are damaged and replaced with scar tissue. This can often lead to cancer. In the United States, the major causes of liver cirrhosis are alcohol abuse and hepatitis B and C. Non-alcoholic fatty liver is a fairly common disease in which people who don't drink alcohol develop a fatty liver. People with a type of fatty liver called non-alcoholic steatohepatitis (NASH) may go on to develop cirrhosis.

Inherited metabolic diseases

  • Certain inherited metabolic diseases can lead to cirrhosis. People with hemochromatosis absorb too much iron from their food. The iron settles in tissues throughout the body, including the liver. If enough iron builds up in the liver, they can get cirrhosis and liver cancer. There are also other rare diseases that increase the risk of liver cancer.

Diabetes

  • Diabetes can increase the risk of liver cancer. This is more common in people with diabetes who also have other risk factors such as heavy drinking and/or chronic hepatitis.

Obesity

  • Being very overweight might increase the risk of getting liver cancer.

Aflatoxins

  • These cancer-causing substances are made by a fungus that can get into peanuts, wheat, soybeans, groundnuts, corn, and rice. Long-term exposure to aflatoxins can increase the risk of liver cancer. In the United States and Europe, these foods are tested for aflatoxins.

Vinyl chloride and thorium dioxide (Thorotrast)

  • These chemicals are risk factors for some types of liver cancer. They have become much less important since Thorotrast is no longer used, and exposure to vinyl chloride is strictly controlled.

Anabolic steroids

  • These male hormones are used by some athletes to increase their strength. Long-term use can slightly increase the risk of liver cancer.

Arsenic

  • Drinking water that comes from wells can have arsenic in it. This increases the risk of liver cancer and is a concern in some parts of the United States.

*Information from the American Cancer Society.